(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

Base Information

Chemical Name:(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone
CAS No.:155486-89-8
Molecular Formula:C₂₀H₂₈O₂
Molecular Weight:300.441
Hs Code.:

Synonyms:(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

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Chemical Property of (-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

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Technology Process of (-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

There total 4 articles about (-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 155393-00-3
(-)-(4aS,6R,8aS)-3.4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone 1-ethylene ketal

: 155486-89-8
(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1248/cpb.41.1698

Reference yield:

: 100-39-0
benzyl bromide

: 155486-89-8
(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide / 5 h / 25 °C

2: 88 percent / 10percent aq. HCl / tetrahydrofuran / 3 h / 25 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1698

Reference yield:

: 155486-87-6
(+)-(4aR,6S,8aR)-3,4,4a,5,6,7,8,8a-octahydro-6-hydroxy-5,5,8a-trimethyl-1(2H)-naphthalenone 1-ethylene ketal

: 155486-89-8
(-)-(4aS,6R,8aS)-3,4,4a,5,6,7,8,8a-octahydro-6-benzyloxy-5,5,8a-trimethyl-1(2H)-naphthalenone

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / NaH / dimethylformamide / 5 h / 25 °C

2: 88 percent / 10percent aq. HCl / tetrahydrofuran / 3 h / 25 °C

With hydrogenchloride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1248/cpb.41.1698