2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Base Information

• Chemical Name: 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine
• CAS No.: 1620147-14-9
• Molecular Formula: C₂₀H₁₃ClF₃N₃O₃S
• Molecular Weight: 467.856

Synonyms:2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property of 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:

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Technology Process of 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

There total 3 articles about 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloro-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine (1620147-13-8) + p-toluenesulfonyl chloride (98-59-9) → 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine (1620147-14-9)

Guidance literature:

With sodium hydroxide; In acetone; at 20 ℃; for 3h;

DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine (90213-66-4) → 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine (1620147-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

2: sodium hydroxide / acetone / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetone; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

4-trifluoromethoxyphenylboronic acid (139301-27-2) → 2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine (1620147-14-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

2: sodium hydroxide / acetone / 3 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; sodium hydroxide; In water; N,N-dimethyl-formamide; acetone; 1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.066

upstream raw materials:

2-chloro-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

p-toluenesulfonyl chloride

2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

4-trifluoromethoxyphenylboronic acid

Downstream raw materials:

N-(2,6-dimethylphenyl)-4-((4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)benzamide

N-(2,6-dimethylphenyl)-4-((7-methyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)benzamide

N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

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