N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

Base Information

Chemical Name:N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide
CAS No.:1620147-15-0
Molecular Formula:C₃₅H₂₈F₃N₅O₄S
Molecular Weight:671.7
Hs Code.:

Synonyms:N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

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Chemical Property of N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

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Technology Process of N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

There total 7 articles about N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1620147-14-9
2-chloro-7-p-toluenesulfonyl-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 787-93-9
ameltolide

: 1620147-15-0
N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 150 ℃; for 4h; Microwave irradiation;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 1620147-13-8
2-chloro-4-(4-(trifluoromethoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1620147-15-0
N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetone / 3 h / 20 °C

2: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In 1,4-dioxane; acetone;
DOI:10.1016/j.bmcl.2014.05.066

Reference yield:

: 90213-66-4
2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine

: 1620147-15-0
N-(2,6-dimethylphenyl)-4-((7-p-toluenesulfonyl)4-(4-(trifluoromethoxy)phenyl)-7H-pyrrole[2,3-d]pyrimidin-2-yl)amino benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C

2: sodium hydroxide / acetone / 3 h / 20 °C

3: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium hydroxide; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; 1: |Suzuki Coupling;
DOI:10.1016/j.bmcl.2014.05.066