[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

Base Information

Chemical Name:[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine
CAS No.:1429869-83-9
Molecular Formula:C₁₉H₁₅BrF₃N₅O
Molecular Weight:466.26
Hs Code.:

Synonyms:[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

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Chemical Property of [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

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Technology Process of [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

There total 5 articles about [3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-09-5
[(R)-5-(5-amino-2-fluoro-phenyl)-5-difluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl]-carbamic acid tert-butyl ester

: 1260670-05-0
3-bromo-8-chloro-[1,7]naphthyridine

: 1429869-83-9
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; tert-butyl alcohol; at 100 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1429870-16-5
5-bromo-3-methyl-pyridine-2-carboxylic acid 1-dimethylamino-meth-(E)-ylideneamide

: 1429869-83-9
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium tert-butylate / tetrahydrofuran / 3 h / Reflux

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 36 h / 130 °C

3: hydrogenchloride / 1,4-dioxane; tert-butyl alcohol / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; potassium tert-butylate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; toluene; tert-butyl alcohol;

Reference yield:

: 1375301-90-8
3-bromo-7H-[1,7]naphthyridin-8-one

: 1429869-83-9
[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 36 h / 130 °C

2: hydrogenchloride / 1,4-dioxane; tert-butyl alcohol / 1 h / 100 °C / Microwave irradiation

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; toluene; tert-butyl alcohol;