5-BroMo-3-Methylpyridine-2-carboxaMide

Base Information

• Chemical Name: 5-BroMo-3-Methylpyridine-2-carboxaMide
• CAS No.: 1400645-41-1
• Molecular Formula: C7H7BrN2O
• Molecular Weight: 215.04728
• Mol file: 1400645-41-1.mol

Synonyms:5-BroMo-3-Methylpyridine-2-carboxaMide;5-BroMo-3-Methyl-pyridine-2-carboxylic acid aMide;5-Bromo-3-methylpicolinamide;5-bromo-3-methyl-2-Pyridinecarboxamide

Chemical Property of 5-BroMo-3-Methylpyridine-2-carboxaMide

Chemical Property:

• PSA: 55.98000
• LogP: 1.95170
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-Bromo-3-methylpyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BroMo-3-Methylpyridine-2-carboxaMide

There total 3 articles about 5-BroMo-3-Methylpyridine-2-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

5-bromo-3-methylpyridine-2-carbonitrile (156072-86-5) → 5-bromo-3-methyl-pyridine-2-carboxylic acid amide (1400645-41-1)

Guidance literature:

With sulfuric acid; trifluoroacetic acid; at 40 ℃;

Reference yield:

5-bromo-3-methylpyridine-2-carboxylic acid (886365-43-1) → 5-bromo-3-methyl-pyridine-2-carboxylic acid amide (1400645-41-1)

Guidance literature:

5-bromo-3-methylpyridine-2-carboxylic acid; With thionyl chloride; for 1h; Reflux;

With ammonia; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.5h; Cooling with ice;

Reference yield:

5-bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester (794592-13-5) → 5-bromo-3-methyl-pyridine-2-carboxylic acid amide (1400645-41-1)

Guidance literature:

With ammonia; In methanol; for 72h; Reflux;

upstream raw materials:

5-bromo-3-methyl-pyridine-2-carboxylic acid ethyl ester

5-bromo-3-methylpyridine-2-carbonitrile

5-bromo-3-methylpyridine-2-carboxylic acid

Downstream raw materials:

8-[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenylamino]-[1,7]naphthyridine-3-carbonitrile

3-bromo-7H-[1,7]naphthyridin-8-one

3-bromo-8-chloro-[1,7]naphthyridine

[3-((R)-5-amino-3-difluoromethyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(3-bromo-[1,7]naphthyridin-8-yl)-amine

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