N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Base Information

Chemical Name:N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid
CAS No.:78854-23-6
Molecular Formula:C₁₄H₁₇NO₃S
Molecular Weight:279.36
Hs Code.:

Synonyms:N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Suppliers and Price of N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

There total 9 articles about N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3492-64-6
sodium benzylmercaptide

: 100895-61-2
N-acetyl-trans-4-(tosyloxy)-L-proline

: 78854-23-6
N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Guidance literature:: In dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)80644-9

Reference yield:

: 40216-83-9
L-4-hydroxyproline methyl ester hydrochloride

: 78854-23-6
N-acetyl-4(S)-(benzylthio)pyrrolidine-2(S)-carboxic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / NaHCO₃ / dioxane; H₂O / 2 h / 23 °C

2: 64 percent / pyridine / 15 h / 0 °C

3: 82 percent / 1M NaOH / methanol / 0 - 23 °C

4: 1) Na metal / 1) EtOH, 30 deg C, 2) DMSO, 16 h

With pyridine; sodium hydroxide; sodium; sodium hydrogencarbonate; In 1,4-dioxane; methanol; water;
DOI:10.1021/jo00023a037