bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Base Information

Chemical Name:bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate
CAS No.:1541167-43-4
Molecular Formula:C₄₆H₄₄Cl₆N₈O₉Si
Molecular Weight:1093.71
Hs Code.:

bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Synonyms:bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Suppliers and Price of bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

There total 6 articles about bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1541167-36-5
(4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

: 112233-74-6
N₂-acetyl-O₆-(diphenylcarbamoyl)guanine

: 1541167-43-4
bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: N₂-acetyl-O₆-(diphenylcarbamoyl)guanine; With N,O-bis-(trimethylsilyl)-acetamide; In acetonitrile; at 80 ℃; for 0.166667h; Inert atmosphere;

(4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate; With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 0 - 20 ℃; for 1.75h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ja411950n

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1541167-43-4
bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

4.1: dichloromethane / 10 h / Reflux; Inert atmosphere

5.1: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

6.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 80 °C / Inert atmosphere

6.2: 1.75 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; N,O-bis-(trimethylsilyl)-acetamide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ja411950n

Reference yield:

: (4R)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-2-ol

: 1541167-43-4
bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

2.1: dichloromethane / 10 h / Reflux; Inert atmosphere

3.1: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 0.17 h / 80 °C / Inert atmosphere

4.2: 1.75 h / 0 - 20 °C / Inert atmosphere

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; In dichloromethane; cyclohexane; acetonitrile;
DOI:10.1021/ja411950n