(4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

Base Information

• Chemical Name: (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate
• CAS No.: 1541167-36-5
• Molecular Formula: C₂₆H₂₈Cl₆N₂O₆Si
• Molecular Weight: 705.322

Synonyms:(4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

Chemical Property of (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

There total 5 articles about (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

bis(2,2,2-trichlorethyl)azodicarboxylate (38857-88-4) + (R)-tert-butyl((2,3-dihydrofuran-3-yl)oxy)diphenylsilane (1541167-31-0) → (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate (1541167-36-5)

Guidance literature:

In cyclohexane; at 20 ℃; for 16h; stereoselective reaction; Inert atmosphere; Irradiation;

DOI:10.1021/ja411950n

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate (1541167-36-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 23 h / 20 °C / Inert atmosphere; Cooling with ice

2: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / -78 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

4: dichloromethane / 10 h / Reflux; Inert atmosphere

5: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

With 1H-imidazole; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja411950n

Reference yield:

(4R)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-2-ol → (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate (1541167-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / -40 °C / Inert atmosphere

2: dichloromethane / 10 h / Reflux; Inert atmosphere

3: cyclohexane / 16 h / 20 °C / Inert atmosphere; Irradiation

With triethylamine; In dichloromethane; cyclohexane;

DOI:10.1021/ja411950n

upstream raw materials:

tert-butylchlorodiphenylsilane

bis(2,2,2-trichlorethyl)azodicarboxylate

(R)-tert-butyl((2,3-dihydrofuran-3-yl)oxy)diphenylsilane

(R)-4-((tert-butyldiphenylsilyl)oxy)dihydrofuran-2(3H)-one

Downstream raw materials:

bis(2,2,2-trichloroethyl) 1-((3R,4R)-2-(2-acetamido-6-((diphenylcarbamoyl)oxy)-9H-purin-9-yl)-4-((tert-butyldiphenylsilyl)oxy)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

bis(2,2,2-trichloroethyl)-1-((3R,4R)-4-((tert-butyldiphenylsilyl)oxy)-2-(5-methyl-2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)tetrahydrofuran-3-yl)hydrazine-1,2-dicarboxylate

1-((3R,4R)-3-amino-4-((tert-butyldiphenylsilyl)oxy)-tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

2-acetamido-9-((3R,4R)-3-amino-4-((tert-butyldiphenylsilyl)oxy)tetrahydro-furan-2-yl)-9H-purin-6-yl diphenylcarbamate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1541167-36-5 (4aR,7R,7aR)-2,2,2-trichloroethyl-7-((tert-butyldiphenylsilyl)oxy)-3-(2,2,2-trichloroethoxy)-4a,6,7,7a-tetrahydro-1H-furo[3,2-e][1,3,4]oxadiazine-1-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send