N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide
CAS No.:1571074-22-0
Molecular Formula:C₄₉H₅₁N₅O₈S₃Si
Molecular Weight:962.256
Hs Code.:

Synonyms:N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Suppliers and Price of N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

There total 4 articles about N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1571067-40-7
1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

: 1571074-22-0
N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

2: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3: dichloromethane / 2 h / 50 °C / Inert atmosphere

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/jo4027148

Reference yield:

: 29684-56-8
Burgess Reagent

: 1571067-44-1
C₄₉H₅₃N₅O₉S₃Si

: 1571074-22-0
N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Guidance literature:: In dichloromethane; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo4027148

Reference yield:

: 1571067-40-7
1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

: 4083-64-1
Tosyl isocyanate

: 1571074-22-0
N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

Guidance literature:: 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile; Tosyl isocyanate; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere;

In ethanol; at 70 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jo4027148