1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

Base Information

• Chemical Name: 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile
• CAS No.: 1571067-40-7
• Molecular Formula: C₄₁H₄₄N₄O₅S₂Si
• Molecular Weight: 765.042
• Mol file: 1571067-40-7.mol

Synonyms:1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

Chemical Property of 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile

There total 1 articles about 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C42H45N3O8S2Si (1571067-39-4) → 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile (1571067-40-7) + 2-((tert-butyldimethylsilyl)oxy)-1,3-bis(1-tosyl-1H-indol-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione (1571067-41-8)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; In dichloromethane; at 0 - 50 ℃; for 30h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield: 63.0%

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile (1571067-40-7) → 1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide (1571067-43-0)

Guidance literature:

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In 1,4-dioxane; water; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1021/jo4027148

Reference yield:

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carbonitrile (1571067-40-7) → C49H53N5O9S3Si (1571067-44-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; 1,4-dioxane / 24 h / 80 °C / Inert atmosphere

2: tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jo4027148

upstream raw materials:

C₄₂H₄₅N₃O₈S₂Si

Downstream raw materials:

N-(2-((tert-butyldimethylsilyl)oxy)-6-oxo-1,3-bis(1-tosyl-1Hindol-3-yl)-5,7-diazaspiro[3.4]octan-8-ylidene)-4-methylbenzenesulfonamide

1-amino-3-((tert-butyldimethylsilyl)oxy)-2,4-bis(1-tosyl-1Hindol-3-yl)cyclobutane-1-carboxamide

C₄₉H₅₃N₅O₉S₃Si