C₅₃H₈₉N₅SiO₁₂

Base Information

• Chemical Name: C₅₃H₈₉N₅SiO₁₂
• CAS No.: 250039-55-5
• Molecular Formula: C₅₃H₈₉N₅O₁₂Si
• Molecular Weight: 1016.4
• Mol file: 250039-55-5.mol

Synonyms:C₅₃H₈₉N₅SiO₁₂

Chemical Property of C₅₃H₈₉N₅SiO₁₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₃H₈₉N₅SiO₁₂

There total 14 articles about C₅₃H₈₉N₅SiO₁₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester (345664-76-8) → C53H89N5SiO12 (250039-55-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1021/ol9910058

Reference yield:

(4R,5S)-4-Benzyloxycarbonylamino-3-hydroxy-5-methyl-heptanoic acid methyl ester → C53H89N5SiO12 (250039-55-5)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.204 g / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 0 - 20 °C

2: NaOH / tetrahydrofuran; methanol; H₂O / 0 - 20 °C

3: 0.5774 g / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / toluene / 0 - 20 °C

4: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 20 °C

5: 0.2315 g / EDAC*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

6: 96 percent / ethyldiisopropylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

7: magnesium bromide diethyl etherate / CH₂Cl₂ / 6 h / 0 - 20 °C

8: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 20 °C

9: 0.173 g / HATU; ethyldiisopropylamine / dimethylformamide / 0 - 20 °C

With morpholine; 2,6-dimethylpyridine; dmap; sodium hydroxide; hydrogen; magnesium bromide ethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol9910058

Reference yield:

(S)-2-Hydroxy-3-methylbutanoic acid (17407-55-5) → C53H89N5SiO12 (250039-55-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 96 percent / anhydrous potassium carbonate; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C

2: 0.5774 g / dicyclohexylcarbodiimide; 4-dimethylaminopyridine / toluene / 0 - 20 °C

3: morpholine / Pd(PPh₃)4 / tetrahydrofuran / 20 °C

4: 0.2315 g / EDAC*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 4.5 h / 0 - 20 °C

5: 96 percent / ethyldiisopropylamine; 4-dimethylaminopyridine / CH₂Cl₂ / 2 h / 0 - 20 °C

6: magnesium bromide diethyl etherate / CH₂Cl₂ / 6 h / 0 - 20 °C

7: H₂ / Pd/C / methanol; ethyl acetate / 5 h / 20 °C

8: 0.173 g / HATU; ethyldiisopropylamine / dimethylformamide / 0 - 20 °C

With morpholine; dmap; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; magnesium bromide ethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ol9910058

upstream raw materials:

4-amino-5-methyl-3-triisopropylsilanyloxy-heptanoic acid 1-[1-(2-{[1-(2-tert-butoxycarbonylamino-2-carboxy-1-methyl-ethoxycarbonyl)-2-(4-methoxy-phenyl)-ethyl]-methyl-carbamoyl}-pyrrolidine-1-carbonyl)-3-methyl-butylcarbamoyl]-2-methyl-propyl ester

(S)-2-Hydroxy-3-methylbutanoic acid

triisopropylsilyl trifluoromethanesulfonate

Z-leucylprolyl-N,O-dimethyltyrosine-O-Boc-threonine-OSEM

Downstream raw materials:

(-)-tamandarin A

Refernces