Organic letters p. 1319 - 1322 (1999)
Update date:2022-08-03
Topics:
Liang
Portonovo
Vera
Xiao
Joullie
[formula: see text] Tamandarin A (1), a newly isolated natural product similar in structure to didemnin B (2), was shown to be somewhat more active in vitro than 2 against pancreatic carcinoma with an ED50 value 1.5 to 2 ng/mL. We report here the first total synthesis of 1. The key steps include a practical stereoselective synthesis of the Hiv-isostatine unit, high-yielding linear precursor formation, a successful macrocyclization, and coupling of the macrocycle with the side chain to afford tamandarin A (1).
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Doi:10.1039/C8CE01917G
(2019)Doi:10.1016/S0040-4020(01)82981-1
(1969)Doi:10.1016/S0957-4166(99)00303-1
(1999)Doi:10.1039/jr9390001069
(1939)Doi:10.1039/a904378k
(1999)Doi:10.1016/S0960-894X(99)00454-0
(1999)