di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Base Information

• Chemical Name: di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate
• CAS No.: 1349734-89-9
• Molecular Formula: C₂₄H₂₆Br₂N₄O₅
• Molecular Weight: 610.302
• Mol file: 1349734-89-9.mol

Synonyms:di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Chemical Property of di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate

There total 4 articles about di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl N-[5-bromo-3-[3-(p-tolyl)isoxazol-5-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate (1349734-88-8) → di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-89-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In fluorobenzene; at 90 ℃; for 1h;

Reference yield:

5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine (875781-41-2) → di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-89-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 20 °C

2.1: sodium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

2.2: 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 1.75 h / 20 - 65 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / fluorobenzene / 1 h / 90 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium carbonate; triethylamine; In fluorobenzene; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

tert-butyl N-tert-butoxycarbonyl-N-[5-bromo-3-((trimethylsilyl)ethyynyl)pyrazin-2-yl]carbamate (1225062-32-7) → di-tert-butyl (5-bromo-3-(3-(4-(bromomethyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate (1349734-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 0.75 h / 75 °C

1.2: 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 1.75 h / 20 - 65 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / fluorobenzene / 1 h / 90 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium carbonate; triethylamine; In fluorobenzene; N,N-dimethyl-formamide;

upstream raw materials:

5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

tert-butyl N-tert-butoxycarbonyl-N-[5-bromo-3-((trimethylsilyl)ethyynyl)pyrazin-2-yl]carbamate

tert-butyl N-(5-bromo-3-ethynyl-pyrazin-2-yl)-N-tert-butoxycarbonyl-carbamate

tert-butyl N-[5-bromo-3-[3-(p-tolyl)isoxazol-5-yl]pyrazin-2-yl]-N-tert-butoxycarbonylcarbamate

Downstream raw materials:

di-tert-butyl (5-bromo-3-(3-(4-((isopropylamino)methyl)phenyl)isoxazol-5-yl)pyrazin-2-yl)carbamate