4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide

Base Information

• Chemical Name: 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide
• CAS No.: 635291-25-7
• Molecular Formula: C₁₄H₁₄ClNO₃S
• Molecular Weight: 311.789
• Mol file: 635291-25-7.mol

Synonyms:4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide

Chemical Property of 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide

There total 3 articles about 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(2S)-2-phenylglycinol (20989-17-7) + 4-chlorobenzenesulfonyl chloride (98-60-2) → 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide (635291-25-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 24h;

Reference yield: 60.8%

(S)-2-Amino-1-phenyl-1-ethanol (56613-81-1,1936-63-6) + 4-chlorobenzenesulfonyl chloride (98-60-2) → 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide (635291-25-7)

Guidance literature:

(S)-2-Amino-1-phenyl-1-ethanol; 4-chlorobenzenesulfonyl chloride; With triethylamine; In dichloromethane; at 20 ℃; for 16h;

With hydrogenchloride; In dichloromethane; water; pH=3;

Reference yield:

2-((4-chlorophenyl)sulfonamido)-2-phenylacetic acid (117309-47-4,251096-79-4) → 4-Chloro-N-[(1S)-2-hydroxy-1-phenylethyl]benzenesulfonamide (635291-25-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2008.05.064

upstream raw materials:

(2S)-2-phenylglycinol

4-chlorobenzenesulfonyl chloride

2-((4-chlorophenyl)sulfonamido)-2-phenylacetic acid

(S)-2-Amino-1-phenyl-1-ethanol