3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

Base Information

Chemical Name:3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine
CAS No.:1301728-34-6
Molecular Formula:C₅₁H₆₆N₂O₉SSi
Molecular Weight:911.245
Hs Code.:

Synonyms:3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

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Chemical Property of 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

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Technology Process of 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

There total 5 articles about 3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 113051-53-9
1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

: 1301728-34-6
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1039/c1cc10138b

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 113051-53-9
1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

: 1301728-34-6
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

: C₅₁H₆₆N₂O₉SSi

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1093/nar/gkv285

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1301728-34-6
3'-O-tert-butyldimethylsilyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-4-O-(2,4,6-triisopropylphenyl)sulfonyluridine

: C₅₁H₆₆N₂O₉SSi

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; pyridine / 12 h

2: 1H-imidazole / dichloromethane / 20 °C

3: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; dmap; triethylamine; In dichloromethane;
DOI:10.1093/nar/gkv285