6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

Base Information

Chemical Name:6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide
CAS No.:1400819-00-2
Molecular Formula:C₁₉H₁₈FIN₄O₅
Molecular Weight:528.279
Hs Code.:

Synonyms:6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

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Chemical Property of 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

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Technology Process of 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

There total 9 articles about 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 391212-29-6
O-(2-vinyloxyethyl)hydroxylamine

: 1373868-80-4
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

: 1400819-00-2
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1400819-00-2
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium nitrite; acetic acid / water / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / 3 h / 20 °C

3.1: thionyl chloride / chloroform / 0 °C / Reflux

3.2: 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: potassium carbonate / water; tetrahydrofuran; methanol / 0 - 70 °C

5.2: pH 3

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

With thionyl chloride; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 868-09-7
2-hydroxyimino-3-oxo-pentanedioic acid dimethyl ester

: 1400819-00-2
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-N-(2-(vinyloxy)ethoxy)-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / 3 h / 20 °C

2.1: thionyl chloride / chloroform / 0 °C / Reflux

2.2: 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0.5 h / 0 °C

4.1: potassium carbonate / water; tetrahydrofuran; methanol / 0 - 70 °C

4.2: pH 3

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

With thionyl chloride; hydrogen; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; mineral oil;