6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

Base Information

Chemical Name:6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid
CAS No.:1373868-80-4
Molecular Formula:C₁₅H₁₁FIN₃O₄
Molecular Weight:443.173
Hs Code.:

Synonyms:6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

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Chemical Property of 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

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Technology Process of 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

There total 7 articles about 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1289572-51-5
methyl 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylate

: 1373868-80-4
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

Guidance literature:: methyl 6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylate; With potassium carbonate; In tetrahydrofuran; methanol; water; at 0 - 70 ℃;

With hydrogenchloride; methanol; water; In tetrahydrofuran; pH=3;

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 1373868-80-4
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium nitrite; acetic acid / water / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / 3 h / 20 °C

3.1: thionyl chloride / chloroform / 0 °C / Reflux

3.2: 0 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

4.2: 0.5 h / 0 °C

5.1: potassium carbonate / water; tetrahydrofuran; methanol / 0 - 70 °C

5.2: pH 3

With thionyl chloride; hydrogen; sodium hydride; potassium carbonate; acetic acid; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; mineral oil;

Reference yield:

: 868-09-7
2-hydroxyimino-3-oxo-pentanedioic acid dimethyl ester

: 1373868-80-4
6-(2-fluoro-4-iodophenylamino)-2,5-dimethyl-4-oxo-4,5-dihydrooxazolo[4,5-c]pyridine-7-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / 3 h / 20 °C

2.1: thionyl chloride / chloroform / 0 °C / Reflux

2.2: 0 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C

3.2: 0.5 h / 0 °C

4.1: potassium carbonate / water; tetrahydrofuran; methanol / 0 - 70 °C

4.2: pH 3

With thionyl chloride; hydrogen; sodium hydride; potassium carbonate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; chloroform; water; mineral oil;