tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

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Chemical Name:tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate
CAS No.:1621399-81-2
Molecular Formula:C₂₉H₃₅FN₆O₅
Molecular Weight:566.633
Hs Code.:

Synonyms:tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

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Technology Process of tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 362670-07-3
(2-amino-5-fluorophenyl)carbamic acid tert-butyl ester

: 1621399-80-1
6-(4-(tert-butoxycarbonyl)piperazin-1-yl)quinoxaline-2-carboxylic acid

: 1621399-81-2
tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 60 ℃;

Reference yield:

: 193902-99-7
tert-butyl 4-(3,4-diaminophenyl)piperazine-1-carboxylate

: 1621399-81-2
tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 20 °C

2: sodium hydroxide; ethanol / tetrahydrofuran / 2 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

With 1-methyl-pyrrolidin-2-one; 1-hydroxy-7-aza-benzotriazole; ethanol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 2369-11-1
5-fluoro-2-nitroaniline

: 1621399-81-2
tert-butyl 4-(2-(2-(tert-butoxycarbonylamino)-4-fluorophenylcarbamoyl)-quinoxalin-6-yl)-piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / N,N-dimethyl-formamide / 100 °C

2: zinc; acetic acid / tetrahydrofuran; ethanol / 0.33 h / Reflux

3: 1-methyl-pyrrolidin-2-one / 20 °C

4: sodium hydroxide; ethanol / tetrahydrofuran / 2 h / 20 °C

5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 60 °C

With 1-methyl-pyrrolidin-2-one; potassium phosphate; 1-hydroxy-7-aza-benzotriazole; ethanol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; zinc; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;