methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

Base Information

Chemical Name:methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate
CAS No.:1257411-80-5
Molecular Formula:C₂₈H₃₅ClN₄O₄
Molecular Weight:527.063
Hs Code.:

Synonyms:methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

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Chemical Property of methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

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Technology Process of methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

There total 1 articles about methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 35444-44-1
methyl adipoyl chloride

: 247085-49-0
N,N-di-n-propyl-[2-(8-amino-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)]acetamide

: 1257411-80-5
methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/mp100235w

Reference yield: 88.0%

: 1257411-80-5
methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

: 1257411-81-6
6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

Guidance literature:: methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate; With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 1h;

With hydrogenchloride; In water; pH=4; Cooling;
DOI:10.1021/mp100235w

Reference yield:

: 1257411-80-5
methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

: 1257411-83-8
N₁-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-yl)-N₆-(1-((2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)adipamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 50 °C

1.2: pH 4 / Cooling

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / 20 °C

3.1: pyridine / 50 °C

With pyridine; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1021/mp100235w