6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

Base Information

Chemical Name:6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid
CAS No.:1257411-81-6
Molecular Formula:C₂₇H₃₃ClN₄O₄
Molecular Weight:513.036
Hs Code.:

Synonyms:6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

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Chemical Property of 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

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Technology Process of 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

There total 2 articles about 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1257411-80-5
methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate

: 1257411-81-6
6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

Guidance literature:: methyl 6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxo-ethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoate; With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 1h;

With hydrogenchloride; In water; pH=4; Cooling;
DOI:10.1021/mp100235w

Reference yield:

: 35444-44-1
methyl adipoyl chloride

: 1257411-81-6
6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / 2 h / 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 50 °C

2.2: pH 4 / Cooling

With potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/mp100235w

Reference yield: 72.0%

: 1257411-81-6
6-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-6-oxohexanoic acid

: 96-53-7
2-mercaptothiazoline

: 1257411-82-7
N-(2-(4-chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-yl)-6-oxo-6-(2-thioxothiazolidin-3-yl)hexanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/mp100235w