N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

Base Information

Chemical Name:N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine
CAS No.:1357082-47-3
Molecular Formula:C₂₁H₂₃F₃N₆
Molecular Weight:416.449
Hs Code.:

Synonyms:N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

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Chemical Property of N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

Chemical Property:

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Technology Process of N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

There total 4 articles about N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1310451-21-8
N‐(3‐bromopropyl)‐N′‐cyanopicolinamidine

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1357082-47-3
N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 4h; Reflux;
DOI:10.1016/j.ejmech.2011.11.023

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 1357082-47-3
N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / 20 °C

1.2: 20 °C

2.1: 4 h / 20 °C / aq. phosphate buffer

3.1: triethylamine / methanol / 18 h / 20 °C

4.1: potassium carbonate; sodium iodide / acetonitrile / 4 h / Reflux

With sodium methylate; potassium carbonate; triethylamine; sodium iodide; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2011.11.023

Reference yield:

: methyl N‐cyano‐2‐pyridinecarboximidate

: 1357082-47-3
N'-cyano-N-(3-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)propyl)picolinamidine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / methanol / 18 h / 20 °C

2: potassium carbonate; sodium iodide / acetonitrile / 4 h / Reflux

With potassium carbonate; triethylamine; sodium iodide; In methanol; acetonitrile;
DOI:10.1016/j.ejmech.2011.11.023