2,4-Dihydroxypyridine

Base Information

• Chemical Name: 2,4-Dihydroxypyridine
• CAS No.: 626-03-9
• Molecular Formula: C5H5NO2
• Molecular Weight: 111.1
• Hs Code.: 29339900
• Mol file: 626-03-9.mol

Synonyms:2(1H)-Pyridone, 4-hydroxy-;2(1H)-Pyridinone, 4-hydroxy-;2-hydroxy-1H-pyridin-4-one;2(1H)-Pyridinone, 4-hydroxy- (9CI);4-Hydroxy-2(1H)-pyridinone;4-Hydroxy-2-pyridone;3-Deazauracil;Pyridine-2,4-diol;

Chemical Property of 2,4-Dihydroxypyridine

Chemical Property:

• Appearance/Colour: white to yellow-beige crystals or cryst. powder
• Vapor Pressure: 0.00192mmHg at 25°C
• Melting Point: 272-276 °C(lit.)
• Refractive Index: 1.637
• Boiling Point: 270.9 °C at 760 mmHg
• PKA: pK1:1.37(+1);pK2:6.45(0);pK3:13(+1) (20°C)
• Flash Point: 117.6 °C
• PSA: 53.35000
• Density: 1.379 g/cm³
• LogP: 0.49280
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO, Methanol
• Water Solubility.: 6.211g/L(20 oC)

Purity/Quality:

99% ^*data from raw suppliers

2,4-Dihydroxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2,4-Dihydroxypyridine (3-deazauracil) was used in the synthesis of diazaphenoxathiin skeleton.

Technology Process of 2,4-Dihydroxypyridine

There total 13 articles about 2,4-Dihydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,4-dimethoxypyridine (18677-43-5) → 3-deazauracil (626-03-9,84719-31-3)

Guidance literature:

With hexamethyldisilathiane; sodium methylate; In various solvent(s); at 180 ℃; for 24h;

DOI:10.3987/COM-92-6197

Reference yield: 38.0%

2-bromo-4-methoxypyridine-3-carbonitrile (98645-42-2) → 4-hydroxy-2-pyridone (626-03-9)

Guidance literature:

With hydrogenchloride; at 160 ℃; for 6.5h;

DOI:10.1002/ardp.19853180602

Reference yield:

→ 3-deazauracil (626-03-9,84719-31-3)

Guidance literature:

With hydrogenchloride; at 190 - 200 ℃;

upstream raw materials:

pyridin-4-ol

2,4-dimethoxypyridine

2,4-dihydroxy-nicotinonitrile

6-chloro-2,4-dihydroxy-nicotinonitrile

Downstream raw materials:

2,4-dichloropyridine

2,4-dibromopyridine

3-chloro-pyridine-2,4-diol

3-bromo-2,4-dihydroxypyridine

Refernces

• 1、 -. "PYRIDONE GPR119 G PROTEIN-COUPLED RECEPTOR AGONISTS". Page/Page column 60. . Retrieved 2009/02/11.
• 2、 Mittelbach,Kastner,Junek. "Syntheses with nitriles LXXI: Synthesis of 4-hydroxynicotinic acid from butadienedicarbonitriles". . p. 481 - 486. Retrieved 2007/10/02.