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Usage

Uses

Used in Pharmaceutical Industry:
2,4-Dimethoxypyridine is used as a building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique chemical structure allows for the creation of diverse molecular entities with potential medicinal properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4-dimethoxypyridine serves as a key component in the synthesis of pesticides and other crop protection agents. Its incorporation into these products enhances their effectiveness in managing pests and diseases, thereby supporting agricultural productivity.
Used in Catalysis Research:
2,4-Dimethoxypyridine is utilized as a potential ligand in catalytic reactions, playing a crucial role in enhancing the efficiency and selectivity of various chemical processes. Its application in catalysis research is significant for the advancement of green chemistry and the development of more sustainable synthetic methods.
Used in Organic Synthesis:
As a versatile intermediate in organic synthesis, 2,4-dimethoxypyridine is employed in the preparation of a wide range of organic compounds. Its reactivity and functional group compatibility make it a valuable component in the synthesis of complex organic molecules for various applications, including materials science, fragrances, and dyes.

InChI:InChI=1/C7H12O/c1-2-3-4-5-6-7-8/h5-7H,2-4H2,1H3/b6-5+

Upstream product

• 26452-80-2 2,4-dichloropyridine 
• 124-41-4 sodium methylate 
• 276251-83-3 2-bromo-4,6-dimethoxypyridine 
• 96246-00-3 3-bromo-2,4-dimethoxypyridine 
• 17228-69-2 2-chloro-4-methoxy-pyridine 
• 1124-33-0 4-nitraminopyridine N-oxide 
• 2408-70-0 2,4,6-tribromopyridine 
• 96245-98-6 2,3-dibromo-4-methoxypyridine 
• 2402-91-7 2,3,4-tribromopyridine 
• 626-03-9 3-deazauracil 
• 186581-53-3 diazomethane 
• 74-88-4 methyl iodide 

Downstream Products

• 41759-19-7 4-methoxy-1-methyl-2-pyridone 
• 52545-13-8 4-methoxypyridin-2-ol 
• 626-03-9 3-deazauracil 
• 1612288-96-6 2-(2-chloro-6-fluorophenyl)-5-(4,6-dimethoxypyridin-3-yl)-1H-pyrrolo[2,3-b]pyridine 
• 915021-19-1 2,4-dimethoxy-5-pyrimidinylboronic acid 
• 1590408-29-9 C₁₄H₁₄N₆O 
• 1590411-12-3 C₁₅H₁₆N₆O 
• 1590411-09-8 C₁₀H₁₀ClN₃O 
• 851607-27-7 5-bromo-4-chloro-2-methoxypyridine 
• 1590403-75-0 C₂₄H₂₁F₄N₃O₄ 
• 1590411-01-0 C₃₂H₂₇F₄N₃O₆ 
• 1590403-76-1 C₂₄H₁₅F₄NO₃ 
• 1590403-66-9 C₂₄H₂₂F₄N₂O₄ 
• 1590403-65-8 C₂₅H₁₇F₄NO₃ 

Relevant academic research and scientific papers

A convenient synthesis of gimeracil

A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2,4-dimethoxypyridine as the starting material with 3,5-dichloro-2,4-dimethoxypyridine and 3,5-dichloro-2,4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.

ANTI-FIBROTIC PYRIDINONES

This application relates to polycyclic compounds with a pyridinone or pyridinone derivative core including, substituted pyridinones, 5,6- and 6,6- bicyclic heterocycles and substituted pyridine-thiones. This application also discloses methods of preparing these polycyclic compounds, pharmaceutical compositions and medicaments comprising said compounds and methods to treat, prevent or diagnose diseases, disorders or conditions associated with fibrosis.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

CHEMICAL COMPOUNDS AND PROCESSES

The present invention relates generally to chemical compounds and methods for their use and preparation. In particular, the invention relates to chemical compounds which may possess useful therapeutic activity, use of these compounds in methods of therapy and the manufacture of medicaments as well as compositions containing these compounds.

NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS

The present invention relates to novel compounds, in particular novel pyridinone derivat ives according to Formula (I) X R1 N Y (I) R2 R3 wherein all radicals are defined in the application. The compounds according to the invention are positive allosteric modulators of metabotropic receptors-subt ype 2 ("mGluR2") which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved. "

Rearrangaments of Azabiphenylenes. The Impact of Nitrogen Number and Position

4-Methoxy-1-azabiphenylene and 1-methoxy-2-azabiphenylene have been synthesized from the appropriate precursor diethynylmethoxypyridines via cobalt-catalyzed cooligomerization with bis(trimethylsilyl)acetylene.When 4-methoxy-1,3-diazabiphenylene was transformed into 1,3-dimethoxyisoquinoline in methanolic sodium methoxide at reflux overnight, 1-methoxy-2-azabiphenylene required longer reflux time and 4-methoxy-1-azabiphenylene required forcing conditions for transformations to occur.The transformations product from the latter was shown to be 1,5-dimethoxy-2-benzazocine and that from the former was established by independent synthesis to be 3-methoxy-1-((E)-2-methoxyethenyl)isoquinoline.The impressive disparity in the products obtained from the methoxydiazabiphenylene and the two methoxyazabiphenylenes can be rationalized by consideration of the locus of methanol addition and sequential electrocyclic reactions.