(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

Base Information

Chemical Name:(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester
CAS No.:118111-40-3
Molecular Formula:C₁₉H₂₄N₂O₆
Molecular Weight:376.409
Hs Code.:

Synonyms:(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

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Technology Process of (2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

There total 3 articles about (2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.3%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 111771-58-5
(2R)-(-)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine

: 118111-40-3
(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

Guidance literature:: With dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; a.) 0 deg C, 4 h, b.) RT, 8 h;
DOI:10.1021/jo00263a004

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 118111-40-3
(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66.8 percent / NaCO₃ / dioxane; H₂O / a.) 5 deg C, 3 h, b.) RT, overnight

2: 86.3 percent / DCC / 1,2-dimethoxy-ethane / a.) 0 deg C, 4 h, b.) RT, 8 h

With dicyclohexyl-carbodiimide; In 1,4-dioxane; 1,2-dimethoxyethane; water;
DOI:10.1021/jo00263a004

Reference yield:

: 17350-84-4
(R)-2-amino-2-methyl-3-phenylpropanoic acid

: 118111-40-3
(2R)-(+)-N-<(1,1-dimethylethyl)oxycarbonyl>-2-methyl-3-phenylalanine N-hydroxysuccinimide ester

Guidance literature:: Multi-step reaction with 2 steps

1: 66.8 percent / NaCO₃ / dioxane; H₂O / a.) 5 deg C, 3 h, b.) RT, overnight

2: 86.3 percent / DCC / 1,2-dimethoxy-ethane / a.) 0 deg C, 4 h, b.) RT, 8 h

With dicyclohexyl-carbodiimide; In 1,4-dioxane; 1,2-dimethoxyethane; water;
DOI:10.1021/jo00263a004