1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

Base Information

Chemical Name:1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate
CAS No.:1350459-99-2
Molecular Formula:C₁₈H₂₂N₄O₆
Molecular Weight:390.396
Hs Code.:

Synonyms:1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

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Chemical Property of 1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

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Technology Process of 1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

There total 1 articles about 1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 129799-08-2
tert-butyl methyl piperazine-1,3-dicarboxylate

: 1350459-99-2
1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 36h; Reflux;

Reference yield:

: 1350459-99-2
1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

: 1350460-01-3
1-tert-butyl 3-methyl 4-(4-amino-2-cyanophenyl)piperazine-1,3-dicarboxylate

Guidance literature:: With water; iron; ammonium chloride; In methanol; for 1h; Reflux;

Reference yield:

: 1350459-99-2
1-tert-butyl 3-methyl 4-(2-cyano-4-nitrophenyl)piperazine-1,3-dicarboxylate

: 1350460-03-5
3-benzyl-2,3,4,4a,6,7-hexahydropyrazino[1,2-a][1,4]benzodiazepin-5(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; ammonium chloride; iron / methanol / 1 h / Reflux

2.1: hypophosphorous acid; sodium nitrite / copper(I) oxide / water / 2 h / 0 °C

2.2: pH 8

3.1: hydrogen; ammonia / Raney_.(R).-nickel / methanol / 48 h / 20 °C / 2068.65 Torr

4.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

5.1: potassium carbonate / acetonitrile / 20 °C / Reflux

With ammonia; water; hydrogen; hypophosphorous acid; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; sodium nitrite; copper(I) oxide; In methanol; dichloromethane; water; acetonitrile;