(3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone

Base Information

• Chemical Name: (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone
• CAS No.: 1350457-03-2
• Molecular Formula: C₂₄H₃₀N₄O₂
• Molecular Weight: 406.528
• Mol file: 1350457-03-2.mol

Synonyms:(3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone

Chemical Property of (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone

There total 9 articles about (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-morpholinocarbonyl chloride (15159-40-7) + 3-benzyl-1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine (1350456-86-8) → (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone (1350457-03-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

tert-butyl methyl piperazine-1,3-dicarboxylate (129799-08-2) → (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone (1350457-03-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h / Reflux

2.1: water; ammonium chloride; iron / methanol / 1 h / Reflux

3.1: hypophosphorous acid; sodium nitrite / copper(I) oxide / water / 2 h / 0 °C

3.2: pH 8

4.1: hydrogen; ammonia / Raney_.(R).-nickel / methanol / 48 h / 20 °C / 2068.65 Torr

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6.1: potassium carbonate / acetonitrile / 20 °C / Reflux

7.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; ammonia; water; hydrogen; hypophosphorous acid; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(I) oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

Reference yield:

2-fluoro-5-nitrobenzonitrile (17417-09-3) → (3-benzyl-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl)(morpholin-4-yl)methanone (1350457-03-2)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 36 h / Reflux

2.1: water; ammonium chloride; iron / methanol / 1 h / Reflux

3.1: hypophosphorous acid; sodium nitrite / copper(I) oxide / water / 2 h / 0 °C

3.2: pH 8

4.1: hydrogen; ammonia / Raney_.(R).-nickel / methanol / 48 h / 20 °C / 2068.65 Torr

5.1: trifluoroacetic acid / dichloromethane / 16 h / 20 °C

6.1: potassium carbonate / acetonitrile / 20 °C / Reflux

7.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

7.2: -78 °C / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With lithium aluminium tetrahydride; ammonia; water; hydrogen; hypophosphorous acid; iron; potassium carbonate; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; copper(I) oxide; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;

upstream raw materials:

tert-butyl 5-oxo-1,2,4a,5,6,7-hexahydropyrazino[1,2-a][1,4]benzodiazepine-3(4H)-carboxylate

2,3,4,4a,6,7-hexahydropyrazino[1,2-a][1,4]benzodiazepin-5(1H)-one

3-benzyl-2,3,4,4a,6,7-hexahydropyrazino[1,2-a][1,4]benzodiazepin-5(1H)-one

4-morpholinocarbonyl chloride

Downstream raw materials:

morpholin-4-yl[3-(phenylsulfonyl)-1,2,3,4,4a,5-hexahydropyrazino[1,2-a][1,4]benzodiazepin-6(7H)-yl]methanone