2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

Base Information

Chemical Name:2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine
CAS No.:630104-52-8
Molecular Formula:C₂₁H₂₄N₂O₆
Molecular Weight:400.431
Hs Code.:

Synonyms:2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

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Chemical Property of 2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

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Technology Process of 2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

There total 12 articles about 2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 630104-51-7
(2S,3S,4R,5R)-4-allyloxy-2-(2',4'-dimethoxypyrimidin-5'-yl)-3-(p-methoxybenzyloxy)-5-vinyltetrahydrofuran

: 630104-52-8
2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 5h; Heating;
DOI:10.1016/j.tet.2005.12.066

Reference yield:

: 630104-50-6
(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

: 630104-52-8
2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / sodium hydride / dimethylformamide / 0 °C

2: 94 percent / first generation Grubbs catalyst / CH₂Cl₂ / 5 h / Heating

With sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide; 2: Grubbs metathesis;
DOI:10.1016/j.tet.2005.12.066

Reference yield:

: 896442-50-5
C₃₂H₅₂N₂O₈Si₂

: 630104-52-8
2,4-dimethoxy-5-[3,7-anhydro-5,6-dideoxy-2-O-para-methoxybenzyl-D-glycero-β-D-allo-hepto-5-enofuranosyl]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / TBAF / tetrahydrofuran / 1 h / 0 °C

2: 91 percent / sodium hydride / dimethylformamide / 0 °C

3: 94 percent / first generation Grubbs catalyst / CH₂Cl₂ / 5 h / Heating

With tetrabutyl ammonium fluoride; sodium hydride; Grubbs catalyst first generation; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Grubbs metathesis;
DOI:10.1016/j.tet.2005.12.066