(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

Base Information

Chemical Name:(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol
CAS No.:630104-50-6
Molecular Formula:C₂₀H₂₄N₂O₆
Molecular Weight:388.42
Hs Code.:

Synonyms:(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

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Chemical Property of (2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

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Technology Process of (2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

There total 12 articles about (2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 896442-50-5
C₃₂H₅₂N₂O₈Si₂

: 630104-50-6
(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2005.12.066

Reference yield: 36.0%

: 1779-49-3
Methyltriphenylphosphonium bromide

: 630104-49-3
C₃₁H₅₂N₂O₉Si₂

: 630104-50-6
(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

Guidance literature:: C₃₁H₅₂N₂O₉Si₂; With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Methyltriphenylphosphonium bromide; With sodium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/ol030095k

Reference yield: 35.0%

: 736993-18-3
C₁₅H₂₀N₂O₅

: 824-94-2
p-methoxybenzyl chloride

: 630104-50-6
(2S,3S,4R,5R)-5-(2',4'-dimethoxypyrimidin-5'-yl)-4-(4'-methoxybenzyloxy)-2-vinyltetrahydrofuran-3-ol

Guidance literature:: C₁₅H₂₀N₂O₅; With acetic acid; In water; for 1h; Heating / reflux;

With di(n-butyl)tin oxide; In toluene; for 2h; Heating / reflux;

p-methoxybenzyl chloride; With tetra-(n-butyl)ammonium iodide; cesium fluoride; more than 3 stages;