(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

Base Information

Chemical Name:(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester
CAS No.:350817-34-4
Molecular Formula:C₃₅H₅₉NO₇
Molecular Weight:605.856
Hs Code.:

Synonyms:(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

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Chemical Property of (S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

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Technology Process of (S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

There total 16 articles about (S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 350817-16-2
(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2S,3S)-2-hydroxy-1,3-dimethyl-pent-4-enyl)-tetradecyl ester

: 350817-34-4
(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

Guidance literature:: With ozone; triphenylphosphine; at -78 ℃;
DOI:10.1055/s-2001-13382

Reference yield:

: 1613724-80-3
(2S,3S,4R,5R)-1,3-dihydroxy-2,4-dimethyloctadecan-5-yl (2S)-3-(benzyloxy)-2-{[(tert-butoxy)carbonyl]amino}propanoate

: 350817-34-4
(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

Guidance literature:: With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1002/hlca.201300255

Reference yield:

: (αR,βS,4S,5S)-β,2,2,5-tetramethyl-α-tridecyl-1,3-dioxan-4-ethanol

: 350817-34-4
(S)-3-Benzyloxy-2-tert-butoxycarbonylamino-propionic acid (R)-1-((1R,2R,3R)-2-hydroxy-1,3-dimethyl-4-oxo-butyl)-tetradecyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

1.2: 2.5 h / 0 °C / Inert atmosphere

2.1: acetic acid / water / 10 h / 20 °C / Inert atmosphere

3.1: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 2 h / 0 °C / Inert atmosphere

With dmap; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; acetic acid; dicyclohexyl-carbodiimide; In dichloromethane; water;
DOI:10.1002/hlca.201300255