4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Base Information

Chemical Name:4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine
CAS No.:437612-48-1
Molecular Formula:C₂₃H₂₁ClFN₅
Molecular Weight:421.905
Hs Code.:

Synonyms:4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Suppliers and Price of 4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

There total 10 articles about 4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: N-cyclopentyl-N'-guanidine hydrochloride

: 437613-11-1
1-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-2-methyl-2-propen-1-one

: 437612-48-1
4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Guidance literature:: With palladium on activated charcoal; air; sodium ethanolate; In ethanol; at 20 ℃; for 16h;
DOI:10.1016/j.tet.2003.02.003

Reference yield:

: 18368-63-3
6-chloro-2-picoline

: 437612-48-1
4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 9 steps

1: 66 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 15 h / 45 °C

2: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating

3: 1,2-dimethoxy-ethane / 0 - 15 °C

4: Et₃N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C

5: 69.7 g / FeCl₂ / 1,2-dimethoxy-ethane / 3 h / Heating

6: 95 percent / POCl₃ / 1 h / 20 °C

7: 90 percent / tetrahydrofuran / -78 - 0 °C

8: 74 percent / manganese dioxide / CH₂Cl₂ / 20 °C

9: 43 percent / NaOEt; Pd/C; air / ethanol / 16 h / 20 °C

With manganese(IV) oxide; sodium hydroxide; palladium on activated charcoal; air; hydroxylamine hydrochloride; sodium ethanolate; triethylamine; iron(II) chloride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/j.tet.2003.02.003

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 437612-48-1
4-[7-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-5-methyl-2-pyrimidinamine

Guidance literature:: Multi-step reaction with 9 steps

1: 66 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / 15 h / 45 °C

2: 86 percent / hydroxylamine hydrochloride; aq. NaOH / methanol / 2 h / Heating

3: 1,2-dimethoxy-ethane / 0 - 15 °C

4: Et₃N / 1,2-dimethoxy-ethane / 2 h / 4 - 20 °C

5: 69.7 g / FeCl₂ / 1,2-dimethoxy-ethane / 3 h / Heating

6: 95 percent / POCl₃ / 1 h / 20 °C

7: 90 percent / tetrahydrofuran / -78 - 0 °C

8: 74 percent / manganese dioxide / CH₂Cl₂ / 20 °C

9: 43 percent / NaOEt; Pd/C; air / ethanol / 16 h / 20 °C

With manganese(IV) oxide; sodium hydroxide; palladium on activated charcoal; air; hydroxylamine hydrochloride; sodium ethanolate; triethylamine; iron(II) chloride; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane;
DOI:10.1016/j.tet.2003.02.003