(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate
CAS No.:849773-56-4
Molecular Formula:C₃₁H₃₈N₂O₇S
Molecular Weight:582.718
Hs Code.:

Synonyms:(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

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Chemical Property of (R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

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Technology Process of (R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

There total 3 articles about (R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 704888-95-9
N-isopropoxy-1,1'-biphenyl-4-sulfonamide

: 849773-54-2
tert-butyl (2S)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate

: 849773-56-4
(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00367

Reference yield: 79.0%

: 849773-56-4
(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

Guidance literature:

Reference yield:

: 40371-50-4
S-4-benzyloxycarbonylamino-2-hydroxybutyric acid

: 849773-56-4
(R)-tert-butyl 8-(biphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 3 h / 95 °C

2: TPP; DEAD / tetrahydrofuran / 5 h / 0 °C

With thiamine diphosphate; diethylazodicarboxylate; In tetrahydrofuran; toluene; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2005.01.024