849773-54-2

Upstream product

• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 40371-50-4 S-4-benzyloxycarbonylamino-2-hydroxybutyric acid 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 501-53-1 benzyl chloroformate 
• 36805-97-7 N,N-dimethylformamide di-tert-butyl acetal 

Downstream Products

• 1061742-69-5 tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[1,1'-(biphenyl-4-yl-sulfonyl)-(benzyloxy)amino]butanoate 
• 1427521-86-5 (R)-4-(((benzyloxy)carbonyl)amino)-1-(tert-butoxy)-1-oxobutan-2-yl 4-nitrobenzoate 
• 1427521-87-6 tert-butyl (2R)-4-{[(benzyloxy)carbonyl]amino}-2-hydroxybutanoate 
• 1428203-72-8 (R,Z)-tert-butyl 4-((6,7-bis(benzyloxy)-3-((tert-butoxycarbonyl)amino)quinolin-2(1H)-ylidene)amino)-2-hydroxybutanoate 
• 1428203-72-8 (R,E)-tert-butyl 4-((6,7-bis(benzyloxy)-3-((tert-butoxycarbonyl)amino)quinolin-2(1H)-ylidene)amino)-2-hydroxybutanoate 
• 1061742-79-7 (R)-tert-butyl 4-benzamido-2-(N-isopropoxybiphenyl-4-ylsulfonamido)butanoate 
• 1061742-95-7 (R)-tert-butyl 2-(N-isopropoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate 
• 1061743-12-1 (R)-tert-butyl 2-(N-isopropoxy-4′-methoxybiphenyl-4-ylsulfonamido)-4-(2-phenylacetamido)butanoate 
• 1061743-02-9 (R)-tert-butyl 8-(4'-methoxybiphenyl-4-ylsulfonyl)-10-methyl-3-oxo-1-phenyl-2,9-dioxa-4,8-diazaundecane-7-carboxylate 
• 1061742-73-1 C₃₇H₄₅N₃O₇SSi 
• 1061742-72-0 C₃₁H₃₀N₂O₇S 
• 1061742-43-5 (R)-benzyl 3-(N-(benzyloxy)biphenyl-4-ylsulfonamido)-4-(hydroxyamino)-4-oxobutylcarbamate 
• 1218922-50-9 tert-butyl (2R)-4-[(benzyloxy)carbonylamino]-2-[(4-bromobenzenesulfonyl)-(benzyloxy)amino]butanoate 
• 1218922-65-6 (R)-tert-butyl 8-(4-(but-2-ynyloxy)phenylsulfonyl)-11,11-dimethyl-3,9-dioxo-1-phenyl-2,10-dioxa-4,8-diazadodecane-7-carboxylate 

Relevant academic research and scientific papers

Buchwald-Hartwig versus Microwave-Assisted Amination of Chloroquinolines: En Route to the Pyoverdin Chromophore

The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80percent, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2 R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.

Diagnostic agents selective against metalloproteases

The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, G and n have the meanings reported in the specification, properly la

Total synthesis of pyoverdin D

Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including δN-formyl-δN-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total synthesis of pyoverdin D.

ARYL-SULPHONAMIDIC DIMERS AS METALLOPROTEASES INHIBITORS

The invention relates to dimeric aryl-sulphonamido compounds endowed with inhibitory activity against metalloproteases MMP, having formula (I) below ???????? (M)-L-(M')?????(I) wherein M and M', the same or different from each other, represent the residues of the mctalloprotcascs inhibitors of formula (II) wherein R, R1, R2, R3, G and n have the meanings reported in the specification; the invention also refers to the process for their preparation, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly in the treatment of degenerative disorders.

Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors

The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings r

N-i-Propoxy-N-biphenylsulfonylaminobutylhydroxamic acids as potent and selective inhibitors of MMP-2 and MT1-MMP

Structural manipulation of the pharmacophoric model of type A selective MMP inhibitors (MMPi), obtained by the insertion of some alkyl substituents R 2 possessing an appropriate geometry, steric bulkiness and lipophilicity, is able to improve p