tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate
CAS No.:1588945-19-0
Molecular Formula:C₂₂H₃₄N₂O₄S
Molecular Weight:422.589
Hs Code.:

Synonyms:tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 455-15-2
1-(methylsufonyl)-4-fluorobenzene

: 1588944-74-4
tert-butyl 4-((1S,2R)-2-(2-aminoethyl)cyclopropyl)piperidine-1-carboxylate

: 1588945-19-0
tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; at 20 - 120 ℃; for 1h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1588944-69-7
benzyl 4-((1R,2R)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carboxylate

: 1588945-19-0
tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 30 °C / 1551.49 Torr

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

2.2: 0.5 h / 20 °C

3.1: 1,2-dichloro-ethane / 3 h / 20 °C

3.2: 2 h / 20 °C

4.1: hydrogen; 10% palladium hydroxide on charcoal / methanol / 30 °C / 1551.49 Torr

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 120 °C / Microwave irradiation; Inert atmosphere

With oxalyl dichloride; 10% palladium hydroxide on charcoal; palladium 10% on activated carbon; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;

Reference yield:

: 1588944-71-1
tert-butyl 4-((1R,2R)-2-(2-hydroxyethyl)cyclopropyl)piperidine-1-carboxylate

: 1588945-19-0
tert-butyl 4-((1S,2R)-2-(2-(4-(methylsulfonyl)phenylamino)ethyl)cyclopropyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

1.2: 0.5 h / 20 °C

2.1: 1,2-dichloro-ethane / 3 h / 20 °C

2.2: 2 h / 20 °C

3.1: hydrogen; 10% palladium hydroxide on charcoal / methanol / 30 °C / 1551.49 Torr

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 120 °C / Microwave irradiation; Inert atmosphere

With oxalyl dichloride; 10% palladium hydroxide on charcoal; hydrogen; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; 1,2-dichloro-ethane;