Technology Process of (2R,3S,4R)-1-acetyl-3,4-bis(benzyloxy)-2-<(1S)-1-benzyloxy-3-(ethoxycarbonyl)propyl>pyrrolidine
There total 6 articles about (2R,3S,4R)-1-acetyl-3,4-bis(benzyloxy)-2-<(1S)-1-benzyloxy-3-(ethoxycarbonyl)propyl>pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
Raney nickel T-4;
In
ethanol;
for 5h;
under 760 Torr;
DOI:10.1246/bcsj.59.3885
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 50percent acetic acid / 1.) water, 30 min, reflux; 2.) pyridine, 0 degC, 18 h
2: 1.) sodium hydride; 2.) pyridine / 1.) DMF, 100 degC, 30 min; 2.) 12 h
4: 1.) mercury(II) chloride, calcium carbonate; 2.) sodium hydride / 1.) acetonitrile, water, 4 h; 2.) THF, ambient temperature, 3 h
5: 86 percent / H2 / Raney nickel T-4 / ethanol / 5 h / 760 Torr
With
pyridine; hydrogen; sodium hydride; acetic acid; calcium carbonate; mercury dichloride;
Raney nickel T-4;
In
ethanol;
DOI:10.1246/bcsj.59.3885
- Guidance literature:
-
Multi-step reaction with 3 steps
2: 1.) mercury(II) chloride, calcium carbonate; 2.) sodium hydride / 1.) acetonitrile, water, 4 h; 2.) THF, ambient temperature, 3 h
3: 86 percent / H2 / Raney nickel T-4 / ethanol / 5 h / 760 Torr
With
hydrogen; sodium hydride; calcium carbonate; mercury dichloride;
Raney nickel T-4;
In
ethanol;
DOI:10.1246/bcsj.59.3885
