tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester

Base Information

• Chemical Name: tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester
• CAS No.: 98694-85-0
• Molecular Formula: C₂₆H₃₁NO₆
• Molecular Weight: 453.535
• Mol file: 98694-85-0.mol

Synonyms:tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester

Chemical Property of tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester

There total 2 articles about tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

benzophenone hydrazone (5350-57-2) + N-tert-Butoxycarbonyl-L-prolyl-L-lactic acid (98694-84-9) → tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester (98694-85-0)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In dichloromethane; at -10 - 0 ℃; for 1h;

DOI:10.1055/s-1985-31255

Reference yield: 82.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + L-Lactic acid diphenylmethyl ester (70362-53-7) → tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester (98694-85-0)

Guidance literature:

With carbonylimidazole; In dichloromethane; 1.) 0 deg C, 1 h, 2.) room temp., 4 days;

DOI:10.1021/je60086a037

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

L-Lactic acid diphenylmethyl ester

benzophenone hydrazone

N-tert-Butoxycarbonyl-L-prolyl-L-lactic acid

Refernces

• 1、 Lapatsanis,Milias,Paraskewas. "A simple method for the preparation of diphenylmethyl esters of N-protected amino acids". . p. 513 - 515. Retrieved 2007/10/02.