70362-53-7

Upstream product

• 5350-57-2 benzophenone hydrazone 
• 119-61-9 benzophenone 
• 79-33-4 L-Lactic acid 
• 908093-98-1 diazodiphenylmethane 

Downstream Products

• 98694-85-0 tert-Butoxycarbonyl-L-prolyl-L-lactic acid diphenylmethyl ester 
• 604002-80-4 C₁₆H₁₇O₃N 
• 128590-61-4 diphenylmethyl (S)-2-Chloropropionate 
• 157567-61-8 (S)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoic acid (R)-1-benzhydryloxycarbonyl-ethyl ester 

Relevant academic research and scientific papers

NOVEL CEPHALOSPORIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

CEPHEM COMPOUND HAVING CATECHOL GROUP

A compound of the formula: wherein X is -N=, -CH=, or the like; W is -CH2- or the like; U is -S- or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R3/su

NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Total Synthesis of the Anthelmintic Cyclodepsipeptide, PF1022A

The anthelmintic cyclooctadepsipeptide PF1022A and its antipode were synthesized starting from L-Nα-Boc-leucine (for PF1022A), D-N4a-Boc-leucine (for the antipode), L-lactic acid, and L-phenyllactic acid using Mitsunobu reaction and/