(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

Base Information

Chemical Name:(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid
CAS No.:1091682-07-3
Molecular Formula:C₃₇H₅₁N₃O₆
Molecular Weight:633.828
Hs Code.:

Synonyms:(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

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Chemical Property of (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

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Technology Process of (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

There total 7 articles about (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1091682-05-1
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

: 1091682-07-3
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

Guidance literature:: (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

With sodium hydroxide; In water;

With hydrogenchloride; pH=2;

Reference yield:

: 359877-52-4
tert-butyl 4-((4-methylphenyl)methyl)aminopiperidine carboxylate

: 1091682-07-3
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 20 h / 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

4.1: hydrogenchloride / ethyl acetate

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

6.3: pH 2

With hydrogenchloride; dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

Reference yield:

: 1091681-70-7
(4-methyl-benzyl)-piperidin-4-yl-carbamic acid benzyl ester hydrochloride

: 1091682-07-3
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2.1: hydrogenchloride / ethyl acetate

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 0 - 20 °C

4.3: pH 2

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane; ethyl acetate;