(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

Base Information

Chemical Name:(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester
CAS No.:1091682-05-1
Molecular Formula:C₄₁H₅₉N₃O₆
Molecular Weight:689.936
Hs Code.:

(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

Synonyms:(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

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Chemical Property of (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

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Technology Process of (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

There total 5 articles about (R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride: 1091681-67-2
[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methyl-benzyl)-carbamic acid benzyl ester hydrochloride

: 204637-77-4
(R)-2-cyclopentyl-methyl-succinic acid 4-tert-butyl ester

: 1091682-05-1
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield:

: 1091681-70-7
(4-methyl-benzyl)-piperidin-4-yl-carbamic acid benzyl ester hydrochloride

: 1091682-05-1
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

2: hydrogenchloride / ethyl acetate

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With hydrogenchloride; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; ethyl acetate;

Reference yield:

: 104-87-0
4-methyl-benzaldehyde

: 1091682-05-1
(R)-N-((S)-1-{4-[benzyloxycarbonyl-(4-methyl-benzyl)-amino]-piperidine-1-carbonyl}-2,2-dimethyl-propyl)-3-cyclopentylmethyl-succinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 4 h / Heating / reflux

1.2: 24 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran; water / 20 h / 20 °C

3.1: hydrogenchloride / ethyl acetate

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

5.1: hydrogenchloride / ethyl acetate

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 18 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;