5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine
• CAS No.: 452309-35-2
• Molecular Formula: C₄₂H₅₁N₃O₁₄
• Molecular Weight: 821.879

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine

There total 5 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminomethyl-15-crown-5 (83585-56-2) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine (452309-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 76.4 percent / acetonitrile / 96 h / 55 °C

2: Et₃N*3HF / tetrahydrofuran / 20 °C

3: 1.248 g / pyridine / ice-cooling

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; acetonitrile;

DOI:10.1039/b111434b

Reference yield:

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine (452309-35-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 98.9 percent / CH₂Cl₂

2: 76.4 percent / acetonitrile / 96 h / 55 °C

3: Et₃N*3HF / tetrahydrofuran / 20 °C

4: 1.248 g / pyridine / ice-cooling

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; dichloromethane; acetonitrile;

DOI:10.1039/b111434b

Reference yield:

2'-O-(imidazol-1-ylcarbonyl)-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)uridine (452309-16-9) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-(1,4,7,10,13-pentaoxacyclopentadecan-2-ylmethylaminocarbonyl)uridine (452309-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 76.4 percent / acetonitrile / 96 h / 55 °C

2: Et₃N*3HF / tetrahydrofuran / 20 °C

3: 1.248 g / pyridine / ice-cooling

With pyridine; triethylamine tris(hydrogen fluoride); In tetrahydrofuran; acetonitrile;

DOI:10.1039/b111434b

upstream raw materials:

4,4'-dimethoxytrityl chloride

(1,4,7,10,13-Pentaoxa-cyclopentadec-2-ylmethyl)-carbamic acid (2R,3R,4R,5R)-2-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-3-yl ester

2-aminomethyl-15-crown-5

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

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