N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

Base Information

Chemical Name:N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide
CAS No.:1607820-55-2
Molecular Formula:C₁₆H₂₁N₇O₃S
Molecular Weight:391.454
Hs Code.:

Synonyms:N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

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Chemical Property of N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

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Technology Process of N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

There total 10 articles about N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1607820-48-3
4-ethoxy-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]-triazin-5-yl)benzene-1-sulfonyl chloride

: 107-15-3,85404-18-8
ethylenediamine

: 1607820-55-2
N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

Guidance literature:: In acetonitrile; at 20 ℃;
DOI:10.1016/j.bmc.2014.10.009

Reference yield:

: 682319-80-8
1,3-dimethyl-5-(methylsulfanyl)-1H-pyrazolo[4,3-e][1,2,4]triazine

: 1607820-55-2
N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2014.03.029

Reference yield:

: 213211-69-9
(2-ethoxyphenyl)boronic acid

: 1607820-55-2
N-(2-aminoethyl)-3-(1,3-dimethyl-1H-pyrazolo[4,3-e][1,2,4]triazin-5-yl)-4-ethoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / Inert atmosphere; Reflux

2: chlorosulfonic acid / 2 h / 0 - 20 °C

3: acetonitrile / 20 °C

With chlorosulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bmc.2014.03.029