5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate

Base Information

• Chemical Name: 5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate
• CAS No.: 95841-69-3
• Molecular Formula: C₃₄H₄₉BrO₃
• Molecular Weight: 585.665
• Mol file: 95841-69-3.mol

Synonyms:5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate

Chemical Property of 5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate

There total 1 articles about 5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7α-bromocholest-5-en-3β-ol benzoate (26048-46-4) → 5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate (95841-69-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In benzene; for 6h; Ambient temperature;

DOI:10.1021/jo00211a009

Reference yield:

5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate (95841-69-3) → 5beta,6beta-Epoxycholestanol (2953-38-0,4025-59-6,24116-45-8,55700-78-2,75764-48-6,97100-48-6,114246-94-5,134356-45-9,1250-95-9)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / methanol / 0.5 h / Heating

2: 48 percent / NaBH₄ / hexamethylphosphoric acid triamide / 6 h / 85 °C

With potassium hydroxide; sodium tetrahydroborate; In methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/jo00211a009

Reference yield:

5β,6β-epoxy-7α-bromocholestan-3β-ol benzoate (95841-69-3) → Benzoic acid (3S,5S,6R,9S,10R,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-3,5-dihydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-6-yl ester (95841-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH / methanol / 0.5 h / Heating

2: 78 percent / t-BuOK / dimethylsulfoxide / 1 h / 55 °C

3: CHCl₃

With potassium hydroxide; potassium tert-butylate; In methanol; chloroform; dimethyl sulfoxide;

DOI:10.1021/jo00211a009

upstream raw materials:

7α-bromocholest-5-en-3β-ol benzoate

Downstream raw materials:

5β,6β-epoxycholest-7-en-3β-ol

Benzoic acid (3S,5S,6R,9S,10R,13R,14R,17R)-17-((R)-1,5-dimethyl-hexyl)-3,5-dihydroxy-10,13-dimethyl-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-6-yl ester

5beta,6beta-Epoxycholestanol