Technology Process of (2Z)-methyl 2-N-benzoylamino-5-methylhexa-2,4-dienoate
There total 4 articles about (2Z)-methyl 2-N-benzoylamino-5-methylhexa-2,4-dienoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Methyl 2-(N-Benzoylamino)-2-(dimethoxyphosphinyl)ethanoate;
With
1,1,3,3-tetramethylguanidine; hydroquinone;
In
tetrahydrofuran;
at -78 ℃;
for 0.5h;
3,3-dimethyl acrylaldehyde;
In
tetrahydrofuran;
at -78 - 25 ℃;
for 18h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: acetone / 19 h / Reflux
2.1: sulfuric acid / 48 h / 20 °C / Cooling with ice
3.1: phosphorus trichloride / toluene / 14 h / 70 °C
3.2: 2 h / 70 °C
4.1: N,N,N',N'-tetramethylguanidine; hydroquinone / tetrahydrofuran / 0.5 h / -78 °C
4.2: 18 h / -78 - 25 °C
With
sulfuric acid; hydroquinone; phosphorus trichloride; N,N,N',N'-tetramethylguanidine;
In
tetrahydrofuran; acetone; toluene;
4.1: |Horner-Wadsworth-Emmons Olefination;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sulfuric acid / 48 h / 20 °C / Cooling with ice
2.1: phosphorus trichloride / toluene / 14 h / 70 °C
2.2: 2 h / 70 °C
3.1: N,N,N',N'-tetramethylguanidine; hydroquinone / tetrahydrofuran / 0.5 h / -78 °C
3.2: 18 h / -78 - 25 °C
With
sulfuric acid; hydroquinone; phosphorus trichloride; N,N,N',N'-tetramethylguanidine;
In
tetrahydrofuran; toluene;
3.1: |Horner-Wadsworth-Emmons Olefination;
