di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Base Information

Chemical Name:di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate
CAS No.:1497422-20-4
Molecular Formula:C₆₁H₉₁N₇O₁₂S
Molecular Weight:1146.5
Hs Code.:

di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Synonyms:di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Chemical Property of di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

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Technology Process of di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

There total 5 articles about di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: C₄₇H₇₉N₅O₁₂

: 1421596-08-8
2-[3-{(2-methylthiazol-4-yl)ethynyl}phenoxy]ethanamine

: 1497422-20-4
di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: C₄₇H₇₉N₅O₁₂; 2-[3-{(2-methylthiazol-4-yl)ethynyl}phenoxy]ethanamine; With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 0.25h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/cn400175m

Reference yield:

: 162148-48-3
(7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

: 1497422-20-4
di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / acetonitrile / 60 °C

2.1: potassium carbonate / acetonitrile / 80 °C

3.1: sodium hydroxide / water; methanol / 20 °C

4.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

4.2: 18 h / 20 °C

With 4-methyl-morpholine; sodium carbonate; potassium carbonate; benzotriazol-1-ol; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/cn400175m

Reference yield:

: C₅₄H₈₅N₅O₁₂

: 1497422-20-4
di-tert-butyl 2,2′-(4-((R)-6-(benzyloxycarbonylamino)-1-tert-butoxy-1-oxohexan-2-yl)-10-((R)-1-tert-butoxy-5-(2-(3-((2-methylthiazol-4-yl)ethynyl)phenoxy)ethylamino)-1,5-dioxopentan-2-yl)-1,4,7,10-tetraazacyclododecane-1,7-diyl)diacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water; methanol / 20 °C

2.1: benzotriazol-1-ol; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.25 h / 0 - 5 °C

2.2: 18 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/cn400175m