N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide

Base Information

• Chemical Name: N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide
• CAS No.: 872217-30-6
• Molecular Formula: C₁₈H₂₇N₃O₅
• Molecular Weight: 365.429
• Mol file: 872217-30-6.mol

Synonyms:N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide

Chemical Property of N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide

There total 1 articles about N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

glycine N'-methoxy-N'-methylamide hydroperchlorate + N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) → N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide (872217-30-6)

Guidance literature:

N-tert-butoxycarbonyl-L-phenylalanine; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -25 ℃;

glycine N'-methoxy-N'-methylamide hydroperchlorate; With sodium hydroxide; In tetrahydrofuran; at -25 - 20 ℃;

DOI:10.1021/jm050686b

Reference yield: 70.0%

N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide (872217-30-6) → [1-(2-oxo-ethylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -35 - 20 ℃;

DOI:10.1021/jm050686b

Reference yield: 55.0%

N-(tert-butoxycarbonyl)-L-phenylalanyl-glycine-N'-methoxy-N'-methylamide (872217-30-6) + methyl magnesium iodide (917-64-6) → N-(N’-α-tert-butyloxycarbonyl-L-phenylalanyl)-1-amino-2-propanone

Guidance literature:

In diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jm050686b

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine