(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

Base Information

Chemical Name:(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine
CAS No.:1196452-63-7
Molecular Formula:C₂₆H₂₉BrN₄O₃
Molecular Weight:525.445
Hs Code.:

Synonyms:(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

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Chemical Property of (1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

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Technology Process of (1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

There total 5 articles about (1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1196452-70-6
1-(3-bromophenyl)-5-iodoindazole

: 1196452-62-6
(1R,2S)-2-amino-3-(tert-butoxy)-1-(6-methoxypyridin-3-yl)propan-1-ol

: 1196452-63-7
(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

Guidance literature:: (1R,2S)-2-amino-3-(tert-butoxy)-1-(6-methoxypyridin-3-yl)propan-1-ol; With caesium carbonate; copper(l) iodide; dimethylaminoacetic acid; In propyl cyanide; at 110 ℃; for 2h;

1-(3-bromophenyl)-5-iodoindazole; In propyl cyanide; at 130 ℃; for 20h;

Reference yield:

: 71989-33-8
Fmoc-Ser(tBu)-OH

: 1196452-63-7
(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0 - 25 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 25 °C

3.1: isopropyl alcohol / aluminum isopropoxide / toluene / 96 h / 65 °C

4.1: piperidine / N,N-dimethyl-formamide / 20 h / 16 - 25 °C

5.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

5.2: 20 h / 130 °C

With piperidine; isopropylmagnesium chloride; caesium carbonate; isopropyl alcohol; 1,1'-carbonyldiimidazole; copper(l) iodide; dimethylaminoacetic acid; aluminum isopropoxide; In tetrahydrofuran; propyl cyanide; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1196452-61-5
9H-fluoren-9-ylmethyl [(1R,2S)-3-tert-butoxy-1-hydroxy-1-(6-methoxypyridin-3-yl)propan-2-yl]carbamate

: 1196452-63-7
(1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: piperidine / N,N-dimethyl-formamide / 20 h / 16 - 25 °C

2.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C

2.2: 20 h / 130 °C

With piperidine; caesium carbonate; copper(l) iodide; dimethylaminoacetic acid; In propyl cyanide; N,N-dimethyl-formamide;