Technology Process of (1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine
There total 5 articles about (1R,2S)-1-{[1-(3-bromophenyl)-1H-indazol-5-yl]oxy}-3-tert-butoxy-1-(6-methoxypyridin-3-yl)propan-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(1R,2S)-2-amino-3-(tert-butoxy)-1-(6-methoxypyridin-3-yl)propan-1-ol;
With
caesium carbonate;
copper(l) iodide; dimethylaminoacetic acid;
In
propyl cyanide;
at 110 ℃;
for 2h;
1-(3-bromophenyl)-5-iodoindazole;
In
propyl cyanide;
at 130 ℃;
for 20h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1,1'-carbonyldiimidazole / dichloromethane / 0 - 25 °C
2.1: isopropylmagnesium chloride / tetrahydrofuran / -15 - 25 °C
3.1: isopropyl alcohol / aluminum isopropoxide / toluene / 96 h / 65 °C
4.1: piperidine / N,N-dimethyl-formamide / 20 h / 16 - 25 °C
5.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C
5.2: 20 h / 130 °C
With
piperidine; isopropylmagnesium chloride; caesium carbonate; isopropyl alcohol; 1,1'-carbonyldiimidazole;
copper(l) iodide; dimethylaminoacetic acid; aluminum isopropoxide;
In
tetrahydrofuran; propyl cyanide; dichloromethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: piperidine / N,N-dimethyl-formamide / 20 h / 16 - 25 °C
2.1: caesium carbonate / copper(l) iodide; dimethylaminoacetic acid / propyl cyanide / 2 h / 110 °C
2.2: 20 h / 130 °C
With
piperidine; caesium carbonate;
copper(l) iodide; dimethylaminoacetic acid;
In
propyl cyanide; N,N-dimethyl-formamide;
