71989-33-8Relevant articles and documents
Method for preparing Fmoc-Ser (tBu)-OH
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, (2020/12/30)
The invention relates to a method for preparing Fmoc-Ser (tBu)-OH, and belongs to the technical field of medical intermediate chemical engineering. The technical problem to be solved by the inventionis to provide a method for preparing Fmoc-Ser (tBu)-OH. The method comprises the following steps: a, enabling Ser-OR. HCl to react with Fmoc-OSu, so as to obtain an Fmoc-Ser-OR solid; b, mixing the Fmoc-Ser-OR solid, tert-butyl acetate, perchloric acid and tert-butyl alcohol, reacting at 15-40 DEG C, regulating the pH value to 5-6, separating out a solid, filtering, washing and drying to obtain anFmoc-Ser (tBu)-OR solid; and c, hydrolysis: carrying out hydrolysis on the Fmoc-Ser (tBu)-ORsolid to obtain an Fmoc-Ser (tBu)-OH product. According to the method, the Fmoc group is introduced firstly, the racemization risk in the saponification process can be reduced, tert-butyl acetate, perchloric acid, tert-butyl alcohol and hydroxyl in Fmoc-Ser-OR are adopted for reaction when tert-butyl is introduced, operation is easy and controllable, safety is good, the obtained product is high in chiral purity and low in cost, the production steps can be effectively shortened, and the production efficiency and yield are improved; the method is suitable for modern industrial production.
MgI2-Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies
Berthet, Mathéo,Davanier, Florian,Dujardin, Gilles,Martinez, Jean,Parrot, Isabelle
supporting information, p. 11014 - 11016 (2015/11/10)
The scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports. Amazing MgI2: Protecting groups have had a tremendous positive impact on the art of biomolecule synthesis. In a context in which the use of attractive protecting groups is often limited by harsh deprotection conditions and low chemoselective flexibility, MgI2 offers, by the execution of a very simple protocol, a fresh vision with extensive perspectives.
NOVEL PEPTIDES DERIVED FROM NCAM (FGLs)
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, (2011/05/05)
The present invention relates to novel compounds comprising at most 13 contiguous amino acid residues derived from the fibronectin type 3,I1 module of neural cell adhesion molecule (NCAM), or a variant or fragment thereof, capable of interacting with an FGFR and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to the use of said compounds for production of a medicament for treatment of conditions and diseases, wherein NCAM and/or FGFR play a prominent role.