(2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

Base Information

Chemical Name:(2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate
CAS No.:1609638-32-5
Molecular Formula:C₂₀H₂₉NO₇
Molecular Weight:395.453
Hs Code.:

Synonyms:(2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

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Chemical Property of (2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

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Technology Process of (2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

There total 1 articles about (2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3587-60-8
Benzyloxymethyl chloride

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 1609638-32-5
(2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

Guidance literature:: dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.833333h;

Benzyloxymethyl chloride; In tetrahydrofuran; hexane; at -78 ℃; for 3.33333h; diastereoselective reaction;
DOI:10.1055/s-0033-1340677

Reference yield: 37.0%

: 1609638-32-5
(2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate

: methyl (2S,4R)-4-(benzyloxymethyl)-5-oxopyrrolidine-2-carboxylate

Guidance literature:: (2R,4S)-dimethyl 2-(benzyloxymethyl)-4-(tert-butoxycarbonylamino)pentanedioate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

In toluene; at 120 ℃; for 12h;