(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate
CAS No.:1609638-33-6
Molecular Formula:C₁₉H₂₅NO₆
Molecular Weight:363.411
Hs Code.:

Synonyms:(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

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Chemical Property of (2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

Chemical Property:

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Technology Process of (2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

There total 4 articles about (2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₁₅H₂₁NO₅

: 1609638-33-6
(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: C₁₅H₂₁NO₅; In toluene; for 48h; Reflux;

di-tert-butyl dicarbonate; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1055/s-0033-1340677

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 1609638-33-6
(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexane / 0.83 h / -78 - 20 °C

1.2: 3.33 h / -78 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: toluene / 48 h / Reflux

3.2: 16 h / 20 °C

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1055/s-0033-1340677

Reference yield:

: 59279-60-6,130622-05-8,861658-15-3
dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

: 1609638-33-6
(2R,4R)-1-tert-butyl 2-methyl 4-(benzyloxymethyl)-5-oxopyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane / tetrahydrofuran; hexane / 0.83 h / -78 - 20 °C

1.2: 3.33 h / -78 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: toluene / 48 h / Reflux

3.2: 16 h / 20 °C

With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane; toluene;
DOI:10.1055/s-0033-1340677