N-(3,5-difluorophenyl)methylidene succinimide

Base Information

• Chemical Name: N-(3,5-difluorophenyl)methylidene succinimide
• CAS No.: 1258432-62-0
• Molecular Formula: C₁₁H₇F₂NO₂
• Molecular Weight: 223.179
• Mol file: 1258432-62-0.mol

Synonyms:N-(3,5-difluorophenyl)methylidene succinimide

Chemical Property of N-(3,5-difluorophenyl)methylidene succinimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,5-difluorophenyl)methylidene succinimide

There total 1 articles about N-(3,5-difluorophenyl)methylidene succinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + N-(3,5-difluorophenyl)maleimide (1020993-59-2) → N-(3,5-difluorophenyl)methylidene succinimide (1258432-62-0)

Guidance literature:

With acetic acid; triphenylphosphine; for 0.666667h; Reflux;

DOI:10.1002/chem.201002183

Reference yield: 63.0%

2-phenyl-4-methyl-4H-oxazolin-5-one (51127-13-0,71963-72-9,87480-74-8,13302-43-7) + N-(3,5-difluorophenyl)methylidene succinimide (1258432-62-0) → C21H16F2N2O4

Guidance literature:

2-phenyl-4-methyl-4H-oxazolin-5-one; With C₂₀H₂₇F₆N₃O; calcium chloride; In dichloromethane; at 25 ℃; for 0.166667h;

N-(3,5-difluorophenyl)methylidene succinimide; In dichloromethane; at 25 ℃; for 4h; enantioselective reaction;

DOI:10.1055/s-0036-1588960

Reference yield:

C15H20FNO2 + N-(3,5-difluorophenyl)methylidene succinimide (1258432-62-0) → C27H28F3NO4 + C27H28F3NO4

Guidance literature:

With 2,6-di-tert-butyl-2,3,5,6-tetrahydro-1H-imidazo[1,2-a]imidazole; In chloroform; at 20 ℃; for 10h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.201002183

upstream raw materials:

formaldehyd

N-(3,5-difluorophenyl)maleimide

Refernces