(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

Base Information

Chemical Name:(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene
CAS No.:886442-71-3
Molecular Formula:C₂₄H₃₃NO₇Si
Molecular Weight:475.614
Hs Code.:

Synonyms:(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

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Chemical Property of (Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

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Technology Process of (Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

There total 10 articles about (Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 886442-63-3
3-((tert-butyldimethylsilyl)oxy)-4-methoxy-2-nitrobenzaldehyde

: 61240-20-8
triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide

: 886442-71-3
(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: With sodium hydride; In dichloromethane; at 0 - 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/cmdc.201402256

Reference yield: 47.0%

: 886442-63-3
3-((tert-butyldimethylsilyl)oxy)-4-methoxy-2-nitrobenzaldehyde

: 61240-20-8
triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide

: 886442-71-3
(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

: (E)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: triphenyl-(3,4,5-trimethoxybenzyl)phosphonium bromide; With sodium hydride; In dichloromethane; at 0 ℃;

3-((tert-butyldimethylsilyl)oxy)-4-methoxy-2-nitrobenzaldehyde; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2005.12.033

Reference yield:

: 6284-92-0
3-hydroxy-4-methoxy-2-nitrobenzaldehyde

: 886442-71-3
(Z)-2-(2'-nitro-3'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 86 percent / 4-(dimethylamino)pyridine; triethylamine / CH₂Cl₂ / 0 °C

2.1: sodium hydride / CH₂Cl₂ / 0 °C

2.2: 47 percent / CH₂Cl₂ / 0 - 20 °C

With dmap; sodium hydride; triethylamine; In dichloromethane; 2.2: Wittig reaction;
DOI:10.1016/j.bmc.2005.12.033